Performance of C-Shaped structural concrete walls subjected to bi-directional loading

Reinforced concrete walls are commonly used as the lateral force resisting system for mid-rise buildings in regions of low and high seismicity. Wall geometries in buildings are generally complex configurations to accommodate architectural constraints during new construction or existing conditions in seismic retrofit applications. A typical configuration for seismic regions is the concrete core-wall system in which coupling beams link a pair of C-shaped walls. While a prevalent structural system, few experimental research programs have examined this wall type and codes of practice have focused on design provisions for planar walls which do not fully account for the effects of non-planar geometry and multi-directional loading. To improve the understanding of the three-dimensional and asymmetric response of coupled core walls, an experimental testing program of C-shaped walls subjected to uni-directional and bi-directional cyclic loading was completed. Three C-shaped walls representative of a ten-story core wall building were tested at the University of Illinois Newmark Structural Engineering Laboratory. Each wall test was subjected to progressively complex loading conditions, and a new stiffness-based loading algorithm was developed to conduct the experiment. Analysis of the experimental data studied the energy dissipation, progression of yielding, components of deformation to total wall drift, base deformations, strain fields generated from displacement field data, and overall displacement profiles of the prototype ten-story building. Subsequent evaluations using prior experimental tests of planar, coupled and non-planar walls identified the aspects of behavior unique to C-shaped walls. The experimental tests exhibited a ductile failure resulting from loss of boundary element confinement, bar buckling, and rupture of the longitudinal bars. However, the ductile failure mechanism was precipitated by increased shear deformation and undesirable shear related damage of base sliding and web crushing. The onset of damage mechanisms, propagation of damage, and drift capacity at failure was identified to be path dependent, and bi-directional loading decreased drift capacity. Effective flexural and shear stiffness values for the elastic analysis of non-planar walls were recommended for design. Design variables and demand to capacity ratios were parametrically studied for non-planar walls as a means to correlate drift capacity and ductility. To supplement the experimental data, a series of non-linear finite element analyses were conducted using a layered shell element model with comprehensive constitutive models capturing the cracked response of reinforced concrete in cyclic biaxial loading conditions. Model validation is conducted using reinforced concrete panel tests, and the impact of crack spacing on prediction is quantified. The resulting analytical models of the C-shaped walls provide a validation of the experimental results and a characterization of shear stress distribution as a function of drift level for strong axis and weak axis loading

Impact of Bi-directional Loading on the Seismic Performance of C-shaped Piers of Core Walls

Reinforced concrete structural walls are commonly used as the primary lateral load resisting system in modern buildings constructed in high seismic regions. Most walls in high-rise buildings are C-shaped to accommodate elevators or other architectural features. C-shaped walls have complex loading and response including: (1) symmetric response in the direction of the web, (2) asymmetric response in the direction of the flange and (3) high compression and shear demands when used as a pier in a coupled-wall configuration. A research study was conducted on C-shaped walls tested under (1) uni-directional and (2) bi-directional loading of an isolated walls and (3) bi-directional loading of a c-shaped pier in a coupled wall system. Each of the walls failed in flexure with strength loss resulting from low-cycle fatigue of the boundary element longitudinal reinforcement with buckling followed by fracture. The damage progression was as follows: (1) cracking at the wall-foundation interface, (2) concrete spalling in the web, (3) buckling and fracture of web reinforcement, (4) spalling in the flanges, (5) buckling and fracture of the bars in the boundary elements. Concrete spalling and steel bar damage occurred at lower strong-axis drift levels for the bi-directionally loaded, resulting in lower drift capacities for these loading protocols. However, for the strong-axis direction, bi-directional loading does not reduce flexural or shear effective stiffness values suggesting that current values are appropriate for design and evaluation of buildings with c-shaped walls

Ocean acidification increases iodine accumulation in kelp-based coastal food webs

Kelp are main iodine accumulators in the ocean, and their growth and photosynthesis are likely to benefit from elevated seawater CO2 levels due to ocean acidification. However, there are currently no data on the effects of ocean acidification on iodine metabolism in kelp. As key primary producers in coastal ecosystems worldwide, any change in their iodine metabolism caused by climate change will potentially have important consequences for global geochemical cycles of iodine, including iodine levels of coastal food webs that underpin the nutrition of billions of humans around the world. Here, we found that elevated pCO2 enhanced growth and increased iodine accumulation not only in the model kelp Saccharina japonica using both short‐term laboratory experiment and long‐term in situ mesocosms, but also in several other edible and ecologically significant seaweeds using long‐term in situ mesocosms. Transcriptomic and proteomic analysis of S. japonica revealed that most vanadium‐dependent haloperoxidase genes involved in iodine efflux during oxidative stress are down‐regulated under increasing pCO2, suggesting that ocean acidification alleviates oxidative stress in kelp, which might contribute to their enhanced growth. When consumed by abalone (Haliotis discus), elevated iodine concentrations in S. japonica caused increased iodine accumulation in abalone, accompanied by reduced synthesis of thyroid hormones. Thus, our results suggest that kelp will benefit from ocean acidification by a reduction in environmental stress however, iodine levels in kelp‐based coastal food webs will increase, with potential impacts on biogeochemical cycles of iodine in coastal ecosystems

Dark sectors 2016 Workshop: community report

This report, based on the Dark Sectors workshop at SLAC in April 2016, summarizes the scientific importance of searches for dark sector dark matter and forces at masses beneath the weak-scale, the status of this broad international field, the important milestones motivating future exploration, and promising experimental opportunities to reach these milestones over the next 5-10 years

Evolutionary genomics of a cold-adapted diatom: Fragilariopsis cylindrus

The Southern Ocean houses a diverse and productive community of organisms1, 2. Unicellular eukaryotic diatoms are the main primary producers in this environment, where photosynthesis is limited by low concentrations of dissolved iron and large seasonal fluctuations in light, temperature and the extent of sea ice3, 4, 5, 6, 7. How diatoms have adapted to this extreme environment is largely unknown. Here we present insights into the genome evolution of a cold-adapted diatom from the Southern Ocean, Fragilariopsis cylindrus8, 9, based on a comparison with temperate diatoms. We find that approximately 24.7 per cent of the diploid F. cylindrus genome consists of genetic loci with alleles that are highly divergent (15.1 megabases of the total genome size of 61.1 megabases). These divergent alleles were differentially expressed across environmental conditions, including darkness, low iron, freezing, elevated temperature and increased CO2. Alleles with the largest ratio of non-synonymous to synonymous nucleotide substitutions also show the most pronounced condition-dependent expression, suggesting a correlation between diversifying selection and allelic differentiation. Divergent alleles may be involved in adaptation to environmental fluctuations in the Southern Ocean

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability

Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015:a systematic analysis for the Global Burden of Disease Study 2015

Background Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress toward the Sustainable Development Goals (SDGs). We aimed to provide updated HALE and DALYs for geographies worldwide and evaluate how disease burden changes with development.Methods We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2015. We calculated DALYs by summing years of life lost (YLLs) and years of life lived with disability (YLDs) for each geography, age group, sex, and year. We estimated HALE using the Sullivan method, which draws from age-specific death rates and YLDs per capita. We then assessed how observed levels of DALYs and HALE differed from expected trends calculated with the Socio-demographic Index (SDI), a composite indicator constructed from measures of income per capita, average years of schooling, and total fertility rate.Findings Total global DALYs remained largely unchanged from 1990 to 2015, with decreases in communicable, neonatal, maternal, and nutritional (Group 1) disease DALYs off set by increased DALYs due to non-communicable diseases (NCDs). Much of this epidemiological transition was caused by changes in population growth and ageing, but it was accelerated by widespread improvements in SDI that also correlated strongly with the increasing importance of NCDs. Both total DALYs and age-standardised DALY rates due to most Group 1 causes significantly decreased by 2015, and although total burden climbed for the majority of NCDs, age-standardised DALY rates due to NCDs declined. Nonetheless, age-standardised DALY rates due to several high-burden NCDs (including osteoarthritis, drug use disorders, depression, diabetes, congenital birth defects, and skin, oral, and sense organ diseases) either increased or remained unchanged, leading to increases in their relative ranking in many geographies. From 2005 to 2015, HALE at birth increased by an average of 2.9 years (95% uncertainty interval 2.9-3.0) for men and 3.5 years (3.4-3.7) for women, while HALE at age 65 years improved by 0.85 years (0.78-0.92) and 1.2 years (1.1-1.3), respectively. Rising SDI was associated with consistently higher HALE and a somewhat smaller proportion of life spent with functional health loss; however, rising SDI was related to increases in total disability. Many countries and territories in central America and eastern sub-Saharan Africa had increasingly lower rates of disease burden than expected given their SDI. At the same time, a subset of geographies recorded a growing gap between observed and expected levels of DALYs, a trend driven mainly by rising burden due to war, interpersonal violence, and various NCDs.Interpretation Health is improving globally, but this means more populations are spending more time with functional health loss, an absolute expansion of morbidity. The proportion of life spent in ill health decreases somewhat with increasing SDI, a relative compression of morbidity, which supports continued efforts to elevate personal income, improve education, and limit fertility. Our analysis of DALYs and HALE and their relationship to SDI represents a robust framework on which to benchmark geography-specific health performance and SDG progress. Country-specific drivers of disease burden, particularly for causes with higher-than-expected DALYs, should inform financial and research investments, prevention efforts, health policies, and health system improvement initiatives for all countries along the development continuum. Copyright (C) The Author(s). Published by Elsevier Ltd.</p